Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation-0

<p><b>Copyright information:</b></p><p>Taken from "Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation"</p><p>http://www.biomedcentral.com/1471-2121/8/32</p><p>BMC Cell Biology 2007;8():32-32.</p><p>Published online 30 Jul 2007</p><p>PMCID:PMC1952058.</p><p></p>achieve their normal size. Other research has indicated that aggregates initiate as small particles of aggregating protein that then travel along microtubules to ultimately collect and form large aggregates [42]. Since the knockdown of results in smaller, more numerous aggregates, ubiquitination by may be needed for small aggregates to come together and form large aggregates. UBC-2 and UBC-22 may normally have an inhibitory role in this process because their knockdown results in larger and less numerous aggregates. Ubiquitination by and may be required to recruit other proteins, such as proteasomes, to the aggregates, thereby allowing aggregates to further increase in size