Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation-2

<p><b>Copyright information:</b></p><p>Taken from "Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation"</p><p>http://www.biomedcentral.com/1471-2121/8/32</p><p>BMC Cell Biology 2007;8():32-32.</p><p>Published online 30 Jul 2007</p><p>PMCID:PMC1952058.</p><p></p>of Ubc RNAi. Yellow color in the Merge columns indicates colocalization with aggregates. In control worms, ubiquitin and proteasomes colocalize to polyglutamine aggregates (top row). RNAi with eliminates localization of both ubiquitin and proteasomes. RNAi with does not disrupt localization of ubiquitin to aggregates, but does remove proteasomes, as expected. RNAi with either , or diminishes localization of ubiquitin and proteasomes to aggregates, whereas and show no effect on colocalization