Schematic representation of our novel and integrative system for discovering candidates for drug-targetable PPIs in binary PPI data

<p><b>Copyright information:</b></p><p>Taken from "An integrative approach for discovering candidates for drug-targetable protein-protein interactions in interactome data"</p><p>http://www.biomedcentral.com/1471-2210/7/10</p><p>BMC Pharmacology 2007;7():10-10.</p><p>Published online 20 Aug 2007</p><p>PMCID:PMC2045083.</p><p></p> The system uses binary PPI data as an input and assesses each PPI based on three independent investigations; detection of protein domains responsible for PPIs, finding SDC-binding pockets on protein surfaces, and evaluating similarities in the assignment of GO terms. By integrating the results of these three investigations, the system discovers candidates for drug-targetable PPIs