New insight into the role of the β3 subunit of the GABA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout-2

<p><b>Copyright information:</b></p><p>Taken from "New insight into the role of the β3 subunit of the GABA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout"</p><p>http://www.biomedcentral.com/1471-2202/8/85</p><p>BMC Neuroscience 2007;8():85-85.</p><p>Published online 10 Oct 2007</p><p>PMCID:PMC2100059.</p><p></p>d female pan-neuronal β3 knockouts were less sensitive to the sedative/hypnotic effects of etomidate (20 mg/kg) as evidenced by the reduced duration of the LORR compared to same sex controls. B. Ethanol-induced (3.5 g/kg) LORR did not differ between controls and pan-neuronal β3 knockouts. C. Etomidate-induced (20 mg/kg) LORR in forebrain selective β3 knockouts was not dependent on gender but knockouts were less sensitive compared to controls. D. Ethanol-induced (3.5 g/kg, i.p.) LORR of forebrain selective knockout mice did not differ compared to controls. *, p < 0.05; **, p ≤ 0.01