The place cell firing probability during exploration-associated sharp wave/ripple (eSWRs) that occurred at different place field locations

<p><b>Copyright information:</b></p><p>Taken from "Place-selective firing contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in open-field exploration"</p><p></p><p>The European Journal of Neuroscience 2007;26(3):704-716.</p><p>Published online Jan 2007</p><p>PMCID:PMC2121123.</p><p>The Authors (2007). Journal Compilation Federation of European Neuroscience Societies and Blackwell Publishing Ltd</p> (A) Firing probability of cells during the course of SWRs at different place field locations. (a1) Place map locations were subdivided into different subfields according to their map rate relative to the peak map rate at the place map centre. The boundaries of different regions are marked by contour lines. (a2) Mean (± SEM) firing probability histogram of eSWRs at different place map locations. The firing probability histogram was calculated separately for SWRs that occurred in different subfields separated by the contour lines in (a1). Inset in (a2): SWR firing probabilities at baseline (−400 ms), SWR window onset (−100 ms) and SWR peak (0 ms) for different SWR locations. Note the non-linear increase of firing rates for place map locations normally having firing rates > 5% of the peak rate during SWRs. (B) Changes in relative firing probabilities during SWR activation. For each time bin the firing probabilities were divided by the firing probability at the place field centre (i.e. > 70%) for the same time bin. The relative firing probabilities as a function of time and place map location were plotted on an intensity plot. Note the gradual expansion of maximum firing probability regions towards the SWR peak times. (C) Mean (± SEM) onset time of the first spike of cells from the beginning of the SWR window at different SWR locations. Note the decreasing mean onset time for place field locations close to the place field maximum. (D) The time of the first spike during eSWR was predicted by both the last pre-SWR spike-times and place field locations of eSWR using a multiple regression. A histogram of multiple correlation coefficients measured for different sessions is shown. (E) A histogram of partial correlation coefficients measuring to what degree the last pre-eSWR spike-times predict the first eSWR spike-times when the effect of eSWR place field location is removed. (F) A histogram of partial correlation coefficients measuring to what degree the eSWR place field location predicts the first eSWR spike-times when the effect of last pre-eSWR spike-times is removed. Grey bars mark significant sessions ( 0.05), while white ones show the non-significant cases. Partial correlation analysis was performed only in those cases where the multiple regression was significant. (G) Average of multiple and partial correlation coefficients over different sessions. loc., place field location; s.t., spike-time