Host predisposition by endogenous Transforming Growth Factor-β1 overexpression promotes pulmonary fibrosis following bleomycin injury-5

<p><b>Copyright information:</b></p><p>Taken from "Host predisposition by endogenous Transforming Growth Factor-β1 overexpression promotes pulmonary fibrosis following bleomycin injury"</p><p>http://www.journal-inflammation.com/content/4/1/18</p><p>Journal of Inflammation (London, England) 2007;4():18-18.</p><p>Published online 20 Sep 2007</p><p>PMCID:PMC2169220.</p><p></p>1 was performed as previously described. Shown are representative micrographs following immunostaining for TGFβ1 in the lung of bleomycin treated, Tr- wild type (A) and Tr+ TGFβ1 transgenic (B) mice. Expression of TGFβ1 is present in both tissue specimens but is substantially enhanced in the Tr+ TGFβ1 transgenic mice. C. Total collagen was determined by hydroxyproline assay as previously described. Collagen production was significantly enhanced in all bleomycin-wounded mice versus control PBS exposed, and in particular collagen deposition has been found higher in Tr+ TGFβ1 transgenic mice than in Tr- Wild Type ones. BLM, Bleomycin