SAHA and IFNα exerted co-operative cytotoxic effects in cancer cell lines, but not in normal non-malignant cells

<p><b>Copyright information:</b></p><p>Taken from "Enhancing the anti-angiogenic action of histone deacetylase inhibitors"</p><p>http://www.molecular-cancer.com/content/6/1/68</p><p>Molecular Cancer 2007;6():68-68.</p><p>Published online 25 Oct 2007</p><p>PMCID:PMC2173905.</p><p></p> Neuroblastoma BE(2)-C, breast cancer MCF-7, and normal non-malignant lung MRC-5 fibroblasts were treated with control, 0.5 μM SAHA and/or 500 IU/ml IFNα for 72 hours. Cell viability was examined using the Alamar blue assay, measured as optical density (OD) units of absorbance, and expressed as the absorbance of treated over control samples (ie., % viable cells). * p < 0.05, ** p < 0.01, *** p < 0.001