Treatment with anti-JAM-C antibody decreases neutrophil infiltration into the joints during antigen-induced arthritis

<p><b>Copyright information:</b></p><p>Taken from "Expression and function of junctional adhesion molecule-C in human and experimental arthritis"</p><p>http://arthritis-research.com/content/9/4/R65</p><p>Arthritis Research & Therapy 2007;9(4):R65-R65.</p><p>Published online 5 Jul 2007</p><p>PMCID:PMC2206366.</p><p></p> Infiltration of neutrophils , lymphocytes , and macrophages into the synovium was detected by immunohistochemistry using anti-MPO, anti-CD3, and anti-MAC-2 antibodies, respectively. The left panels show representative knee joint sections of control and anti-JAM-C antibody-treated mice. Original magnification × 400 (scale bar = 25 μm). In the right panels, leukocyte infiltration per field was evaluated by semi-quantitative scoring for anti-JAM-C antibody-treated (= 6, black columns) and isotype-matched control antibody-treated (= 5, open columns) mice. There was a significant decrease in synovial neutrophil infiltration in anti-JAM-C antibody-treated mice as compared to isotype-matched antibody-treated controls. *< 0.05 versus control mice, as assessed by analysis of variance. Ab, antibody; JAM-C, junctional adhesion molecule-C