Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex-3

<p><b>Copyright information:</b></p><p>Taken from "Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex"</p><p>http://www.biomedcentral.com/1471-2164/8/413</p><p>BMC Genomics 2007;8():413-413.</p><p>Published online 12 Nov 2007</p><p>PMCID:PMC2211497.</p><p></p>s of (phospholipid scramblase 4) and (empty spiracles homolog 2 (Drosophila)) mRNA transcripts were determined for suicide completers vs. non-suicide groups within both bipolar disorder and schizophrenia in prefrontal cortex by qRT-PCR. The bars represent mean ± SEM. In schizophrenia, the mean expression levels of both genes were significantly down-regulated in the suicide group (n = 5) relative to the non-suicide cases (n = 25) by one-tailed, t-tests for unequal variances (t(9) = 2.42, p = 0.02; t(18) = 3.77, p = 0.0005). The estimated fold changes in the suicide group were -1.51 for and -2.16 for relative to the non-suicide group, consistent with our microarray data. In the bipolar disorder samples, no significant differences in mean expression levels for either gene were found between the suicide (n = 14 for ; n = 12 for ) vs. non-suicide cases (n = 15 for ; n = 11 for ) by unequal variance t-tests. * p < .05 ; *** p < .001