Schematic representation of P-cadherin positive and negative breast cancer histological types

<p><b>Copyright information:</b></p><p>Taken from "P-cadherin expression in breast cancer: a review"</p><p>http://breast-cancer-research.com/content/9/5/214</p><p>Breast cancer research : BCR 2007;9(5):214-214.</p><p>Published online 31 Oct 2007</p><p>PMCID:PMC2242663.</p><p></p> In normal breast, P-cadherin is only expressed by myoepithelial cells and not by luminal epithelial cells. In the low-grade arm of breast carcinomas, the majority of lesions are negative for P-cadherin expression, such as invasive lobular carcinomas (ILC), tubular carcinomas, and well differentiated ductal carcinoma (DCIS) and invasive ductal carcinomas (IDC). In the other arm, high-grade lesions are frequently positive for this cadherin, including the medullary carcinomas, a subset of poor-differentiated DCIS and IDC, and the metaplastic carcinomas, which represent a clear subtype of basal-like carcinomas