Regulation of the growth and pulmonary metastasis of breast cancer cells by PRDX6 in studies

<p><b>Copyright information:</b></p><p>Taken from "Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer"</p><p>http://breast-cancer-research.com/content/9/6/R76</p><p>Breast Cancer Research : BCR 2007;9(6):R76-R76.</p><p>Published online 2 Nov 2007</p><p>PMCID:PMC2246172.</p><p></p> The growth curves for different MDA-MB-231 and MDA-MB-435 cells in an proliferation assay. Photomicrographs of micrometastases (arrow) in lung sections obtained from mice bearing parental (), vector-transfected (), PRDX6-transfected () and PRDX6 knockdown () groups for MDA-MB-231 and MDA-MB-435 cells (H & E; × 200). Metastasis numbers per lung in parental, vector-transfected, PRDX6-transfected and PRDX6 knockdown groups at week 8 for MDA-MB-435 cells. The relative protein expression of PRDX6, uPAR, Ets-1, MMP-9, RhoC and TIMP-2 was normalized to the signal intensity of β-actin for MDA-MB-231 and MDA-MB-435 cells. MMP, matrix metalloproteinase; PRDX, peroxiredoxin; TIMP, tissue inhibitor of MMP; uPAR, urokinase-type plasminogen activator receptor; Ets-1, E26 transformation-specific-1; RhoC, ras homolog gene family member C