Lethality from cecal ligation and puncture (CLP) is decreased in BALB/c mice administered an anti-RAGE monoclonal antibody (mAb)

<p><b>Copyright information:</b></p><p>Taken from "Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection"</p><p>http://ccforum.com/content/11/6/R122</p><p>Critical Care 2007;11(6):R122-R122.</p><p>Published online 6 Nov 2007</p><p>PMCID:PMC2246216.</p><p></p> The Kaplan-Meier survival analysis following CLP compares anti-RAGE mAb-treated animals given 7.5 mg/kg (= 15) or 15 mg/kg (= 15) intravenously 30 to 60 minutes before CLP with serum control animals (= 15). The group given 15 mg/kg had a significantly greater survival than the group given 7.5 mg/kg (< 0.05) or serum control (< 0.001). RAGE, receptor for advanced glycation end products