Study of experimental pneumococcal meningitis using magnetic resonance imaging-3

<p><b>Copyright information:</b></p><p>Taken from "study of experimental pneumococcal meningitis using magnetic resonance imaging"</p><p>http://www.biomedcentral.com/1471-2342/8/1</p><p>BMC Medical Imaging 2008;8():1-1.</p><p>Published online 14 Jan 2008</p><p>PMCID:PMC2253532.</p><p></p>ters from 6 to 48 hours after inoculation in infected (n = 29, open circles and solid median line) and control rats (n = 13, black circles and dashed median line). Graph (a) and (b) show median and interquartile range of bacterial counts and WBC counts. Graph (c) and (d) show the steady worsening of clinical disease and deteriorating motor performance among infected animals. The ventricle-brain ratio (VBR) in (e) was subject to marked development among infected rats from 30 hours after infection and all infected rats had increased VBR from 36 hours onwards (P < 0.0001). The number of enhancing cortical voxels (f), indicative of BBB breakdown, was significantly increased among meningitis rats (6 to 48 hours, P = 0.0019). Graphs (g) and (h) illustrate comparable ADC values in cortex and basal ganglia among infected rats with increased variation around the mean values from the control group until 36 hours after infection (P > 0.05). Graph (i) shows decreased areas of high ΔSImuscle (no. of voxels) in infected rats presented as a fraction of the value in corresponding control animals at time point (P = 0.05). Graphs (j), (k) and (l) show the total number of voxels (enhancing + non-enhancing) in each ΔSIcategory (P > 0.05)