Dystrophin deficiency in canine X-linked muscular dystrophy in Japan (CXMD) alters myosin heavy chain expression profiles in the diaphragm more markedly than in the tibialis cranialis muscle-5

<p><b>Copyright information:</b></p><p>Taken from "Dystrophin deficiency in canine X-linked muscular dystrophy in Japan (CXMD) alters myosin heavy chain expression profiles in the diaphragm more markedly than in the tibialis cranialis muscle"</p><p>http://www.biomedcentral.com/1471-2474/9/1</p><p>BMC Musculoskeletal Disorders 2008;9():1-1.</p><p>Published online 9 Jan 2008</p><p>PMCID:PMC2257929.</p><p></p>scle and diaphragm of a normal (A) or an affected dog (B, C) at adolescent (2 or 4 months old) or adult stages (10 or 11 months old). The numbers under the ages show total fibers examined. MHC expression between two groups (normal, dMHC (-) affected, dMHC (-); affected, dMHC (-) affected, dMHC (+)), between muscles (TC muscle diaphragm), or among ages (2, 4, and 10 or 11 months) was analyzed by Yates's chi-square test. Significant differences (< 0.05) were detected in all tests, except for no significant differences between 4 and 10 months old in normal TC muscles or diaphragms. Note that slow MHC fibers were consistently larger than other fibers, in populations of muscle fibers without developmental MHC of affected diaphragms. In populations of muscle fibers co-expressing developmental MHC and other MHC isoform(s), slow MHC and hybrid fibers were increased markedly in the affected diaphragm at 4 and 11 months old, unlike TC muscles