Control of cell cycle entry and exiting from the second mitotic wave in the developing eye-5

Cyclin E level (red) is up-regulated. (G-I) In mutant cells, BrdU (red) is not incorporated in the SMW. (J-L) mutant cells have high level of Cyclin E protein (red). Mutant clones were marked by the absence of GFP (A-L). In all discs, anterior is to the left. White arrowheads in these and subsequent figures indicate the position of the SMW. The over-expression of Cyclin E (M) or Cdk2 (N) alone is not able to induce ectopic BrdU incorporation (red) in mutant clones. (O) Simultaneous over-expression of Cyclin E and Cdk2 induces large number of BrdU incorporation in mutant cells. MARCM clones were marked by the GFP (M-O).<p><b>Copyright information:</b></p><p>Taken from "Control of cell cycle entry and exiting from the second mitotic wave in the developing eye"</p><p>http://www.biomedcentral.com/1471-213X/8/7</p><p>BMC Developmental Biology 2008;8():7-7.</p><p>Published online 24 Jan 2008</p><p>PMCID:PMC2267170.</p><p>