Inal morphology was analyzed 10 days thereafter. Dark-adapted knockout mice served as controls (dark control). Hypoxic preconditioning almost completely protected the retina of p21mice leading to a retinal morphology indistinguishable from controls. Exposure of normoxic mice led to a complete degeneration of photoreceptors in the central retina. Shown are representative samples of control and light exposed mice. n = 2 (controls); n = 4 (light exposed mice). Abbreviations as in Fig. 1. Scale bar: 25 μm.<p><b>Copyright information:</b></p><p>Taken from "Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection"</p><p>http://www.biomedcentral.com/1471-2164/9/73</p><p>BMC Genomi...
Hypoxic preconditioning protects photoreceptors against light-induced degeneration preserving retina...
Background: We aimed to identify global blood and retinal gene expression patterns in murine oxygen-...
Purpose: The DBA/2J (D2) mouse carries mutations in two of its genes, Tyrp1 and Gpnmb. These alterat...
Sed to 5'000 lux of white light for 1 h. Control animals were not preconditioned and were (normoxic)...
Red: induction; green: repression; white: unaffected; colour intensity correlates with fold change.<...
F differentially regulated genes decreased rapidly during reoxygenation, indicating a fast return to...
Fter a period of 2 h, 4 h or 16 h of reoxygenation as determined by real-time PCR. Fold-changes are ...
Purpose: Hyperoxia is specifically toxic to photoreceptors, and this toxicity may be important in th...
PURPOSE: To assess the vulnerability of retinal photoreceptors in the BALB/cJ, C57BL/6J, and C57BL/6...
This study examined the impact of prolonged (up to 35 day) exposure to hyperoxia on the morphology a...
Oxygen delivery to the retinal pigment epithelium and the outer retina is essential for metabolism, ...
Purpose. To assess the vulnerability of retinal photoreceptors in the BALB/cJ, C57BL/6J, and C57BL/6...
Reduced oxygenation of the outer retina in the aging eye may activate a chronic hypoxic response in ...
Understanding the molecular pathways mediating neuronal function in retinas can be greatly facilitat...
The death of neuronal cells is a part of the normal development of mammalian central nervous system,...
Hypoxic preconditioning protects photoreceptors against light-induced degeneration preserving retina...
Background: We aimed to identify global blood and retinal gene expression patterns in murine oxygen-...
Purpose: The DBA/2J (D2) mouse carries mutations in two of its genes, Tyrp1 and Gpnmb. These alterat...
Sed to 5'000 lux of white light for 1 h. Control animals were not preconditioned and were (normoxic)...
Red: induction; green: repression; white: unaffected; colour intensity correlates with fold change.<...
F differentially regulated genes decreased rapidly during reoxygenation, indicating a fast return to...
Fter a period of 2 h, 4 h or 16 h of reoxygenation as determined by real-time PCR. Fold-changes are ...
Purpose: Hyperoxia is specifically toxic to photoreceptors, and this toxicity may be important in th...
PURPOSE: To assess the vulnerability of retinal photoreceptors in the BALB/cJ, C57BL/6J, and C57BL/6...
This study examined the impact of prolonged (up to 35 day) exposure to hyperoxia on the morphology a...
Oxygen delivery to the retinal pigment epithelium and the outer retina is essential for metabolism, ...
Purpose. To assess the vulnerability of retinal photoreceptors in the BALB/cJ, C57BL/6J, and C57BL/6...
Reduced oxygenation of the outer retina in the aging eye may activate a chronic hypoxic response in ...
Understanding the molecular pathways mediating neuronal function in retinas can be greatly facilitat...
The death of neuronal cells is a part of the normal development of mammalian central nervous system,...
Hypoxic preconditioning protects photoreceptors against light-induced degeneration preserving retina...
Background: We aimed to identify global blood and retinal gene expression patterns in murine oxygen-...
Purpose: The DBA/2J (D2) mouse carries mutations in two of its genes, Tyrp1 and Gpnmb. These alterat...