Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase-1

four days and after 2, 4 and 6 passages the relative presence of both viruses in the culture was determined by sequencing. Shown are two representative experiments. The variability in each independent experiment is indicated by ± standard error of the mean (SEM). A: Pat A (E40F, M41L, K43E, M184V, L210W, T215Y and K219T) versus Pat A-WT43 (E40F, M41L, M184V, L210W, T215Y and K219T). B: wild type versus wild type+K43E. C: M41L+T215Y versus M41L+T215Y+K43E. D: M41L+T215Y+E40F versus M41L+T215Y+E40F+K43E.<p><b>Copyright information:</b></p><p>Taken from "Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase"</p><p>http://www.retrovirology.com/content/5/1/20</p><p>Retrovirology 2008;5():20-20.</p><p>Published online 13 Feb 2008</p><p>PMCID:PMC2276231.</p><p>