Interleukin-1 receptor antagonist (IL-1ra) reduces the amount of tyrosine hydroxylase-immunoreactive (TH-ir) cell loss associated with LPS and 6-OHDA (t-test, * 0

05). Each animal received LPS into the substantia nigra (SN), 9 days later started on either IL-1ra or vehicle (Veh) which continued through the experiment, and all animals then received an intra-striatal injection of 6-OHDA (5.0 μg) and were allowed 21 days until post-mortem analyses. Magnification, 2.5×; scale bar, 1.0 mm. Error bars, ± SEM; n = 8 per condition.<p><b>Copyright information:</b></p><p>Taken from "Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease"</p><p>http://www.jneuroinflammation.com/content/5/1/8</p><p>Journal of Neuroinflammation 2008;5():8-8.</p><p>Published online 27 Feb 2008</p><p>PMCID:PMC2292163.</p><p>