Comparative analysis of , , and expression pattern during embryonic development

Medaka embryos at different developmental stages (as indicated in the panels) were hybridized with specific probes, as indicated on the top of each column. Anterior dorsal views; frontal vibratome sections through the eye. From St16 to St19, only and are expressed in the anterior neural plate (panels a to c) and then in the presumptive telencephalon and optic vesicles (panels d to i), although is more abundant in the optic vesicles (panels d and g) and in the telencephalic region (arrowheads in panels e and h). From St22 onward, when mRNA also becomes detectable, the three genes are co-expressed, albeit at different levels, in the developing neural retina, optic stalk, and pre-optic and hypothalamic area (panels j to r). In addition, is distributed in the developing lens, olfactory pits (panels k and n; arrow), telencephalon, and anterior and posterior thalamus (panels k, n, and q). During retinal neurogenesis, and are restricted to the retinal ganglion and amacrine cells (panels t and u), whereas is restricted to the inner nuclear layer (panel s).<p><b>Copyright information:</b></p><p>Taken from "Comprehensive characterization of the -regulatory code responsible for the spatio-temporal expression of in the developing medaka forebrain"</p><p>http://genomebiology.com/2007/8/7/R137</p><p>Genome Biology 2007;8(7):R137-R137.</p><p>Published online 6 Jul 2007</p><p>PMCID:PMC2323233.</p><p>