Squares indicate male subjects; circles, female subjects; solid symbols, affected family members with JOAG; unfilled symbols, unaffected family members; diagonal line, deceased individual. Arrow indicates the proband (III:7). According to the distribution of the affected members, the heredity of the GZ.1pedigree is autosomal dominant.<p><b>Copyright information:</b></p><p>Taken from "Pro370Leu gene mutation in a large Chinese family with juvenile-onset open angle glaucoma: correlation between genotype and phenotype"</p><p></p><p>Molecular Vision 2008;14():1533-1539.</p><p>Published online 22 Aug 2008</p><p>PMCID:PMC2518531.</p><p></p
Purpose: To evaluate the individual and interactive effects of polymorphisms in the myocilin (MYOC),...
<p>(<b>A</b>) Pedigree and haplotype analysis showing segregation of markers across chromosome 9cen,...
Glaucoma is one of the leading causes of irreversible blindness in the world and is characterized by...
Suspects are marked with a question mark inside the squares. Roman numerals and Arabian numerals ind...
1 pedigree. Representative chromatogram contains sequence from the noncoding DNA strand. The locatio...
<p>A four-generation Chinese family affected with autosomal dominant cataract is shown. Squares and ...
AIM: To identify the mutations of MYOC, OPTN, CYP1B1 and WDR36 in a large Chinese family affected by...
<p>Segregation analysis of three nonsynonmous variants: (<b>1A)</b> represents segregation of p.Arg4...
Background: Glaucoma is a major cause of irreversible blindness worldwide. There is evidence showing...
The proband is marked with an arrow. Eight markers are listed from top to bottom: telomere - DXS6807...
AIM: To investigate a Chinese autosomal dominant congenital cataract(ADCC)family and to find the rel...
Purpose: Glaucoma is the second leading cause of blindness. In India, ~1.5 million people are blind ...
<p>(A) A Chinese family that has had autosomal dominant cataracts. The arrow indicates the proband. ...
<p>(<b>A</b>) Pedigree of Family 1. Squares represent males, circles females, black symbols affected...
AIM: To detect the mutations in two candidate genes, myocilin (MYOC) and cytochrome P450 1B1 (CYP1B1...
Purpose: To evaluate the individual and interactive effects of polymorphisms in the myocilin (MYOC),...
<p>(<b>A</b>) Pedigree and haplotype analysis showing segregation of markers across chromosome 9cen,...
Glaucoma is one of the leading causes of irreversible blindness in the world and is characterized by...
Suspects are marked with a question mark inside the squares. Roman numerals and Arabian numerals ind...
1 pedigree. Representative chromatogram contains sequence from the noncoding DNA strand. The locatio...
<p>A four-generation Chinese family affected with autosomal dominant cataract is shown. Squares and ...
AIM: To identify the mutations of MYOC, OPTN, CYP1B1 and WDR36 in a large Chinese family affected by...
<p>Segregation analysis of three nonsynonmous variants: (<b>1A)</b> represents segregation of p.Arg4...
Background: Glaucoma is a major cause of irreversible blindness worldwide. There is evidence showing...
The proband is marked with an arrow. Eight markers are listed from top to bottom: telomere - DXS6807...
AIM: To investigate a Chinese autosomal dominant congenital cataract(ADCC)family and to find the rel...
Purpose: Glaucoma is the second leading cause of blindness. In India, ~1.5 million people are blind ...
<p>(A) A Chinese family that has had autosomal dominant cataracts. The arrow indicates the proband. ...
<p>(<b>A</b>) Pedigree of Family 1. Squares represent males, circles females, black symbols affected...
AIM: To detect the mutations in two candidate genes, myocilin (MYOC) and cytochrome P450 1B1 (CYP1B1...
Purpose: To evaluate the individual and interactive effects of polymorphisms in the myocilin (MYOC),...
<p>(<b>A</b>) Pedigree and haplotype analysis showing segregation of markers across chromosome 9cen,...
Glaucoma is one of the leading causes of irreversible blindness in the world and is characterized by...