Synergistic effects of mitochondrial complex II deficits and dopamine on striatal neuron degeneration

Cell viability assessed by the MTT assay after treatment for 24 h with 3-NP (75 µ), an irreversible inhibitor of mCII, and DA (100 µ). Note that when applied alone, 3-NP is non-toxic and DA is very mildly toxic. Treatment with both agents synergistically induces cell death. * < 0.0001; ANOVA and Fisher's PLSD test.<p><b>Copyright information:</b></p><p>Taken from "Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II"</p><p></p><p>Human Molecular Genetics 2008;17(10):1446-1456.</p><p>Published online 11 Feb 2008</p><p>PMCID:PMC2367694.</p><p>© 2008 The Author(s)