D2 receptor inhibition reduces the DA-induced loss of mCII subunit expression and activity

Neurons were treated with 100 µ DA for 24 h in the presence or absence of the D2 receptor antagonists spiperone (SPI) and haloperidol (HAL), and the D1 receptor antagonist SCH23390 (SCH). () Quantification of the catalytic activity of mCII (succinate dehydrogenase). () Western blot analysis of Fp and Ip corresponding to the culture wells analyzed for mCII activity above. In both cases, the blockade of D2 receptors abolishes the loss of mCII triggered by DA, while D1 receptor blockade has no effect. * < 0.05; ANOVA and Fisher's PLSD test.<p><b>Copyright information:</b></p><p>Taken from "Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II"</p><p></p><p>Human Molecular Genetics 2008;17(10):1446-1456.</p><p>Published online 11 Feb 2008</p><p>PMCID:PMC2367694.</p><p>© 2008 The Author(s)