Genome hybridization to compare the progenitor strains NIH12 and NIH433 to the reference strain JEC21

Regions with higher variability in Log2 ratios in the test genomes are more divergent from the JEC21 sequence; regions with Log2 ratios close to zero have greater similarity (Additional data file 1). A reciprocal pattern of similar and divergent segments is found upon hybridization of genomes of NIH12 and NIH433 to the JEC21 array. The scale of chromosome coordinates for the JEC21 genome is indicated at the top of the figure, and gaps in the chromosomes represent putative centromeric regions [46]. The borders of segments are probable sites of recombination events that occurred during the mating of NIH12 and NIH433, and the subsequent backcrossing to obtain JEC21 (Additional data file 2) [59].<p><b>Copyright information:</b></p><p>Taken from "Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen "</p><p>http://genomebiology.com/2008/9/2/R41</p><p>Genome Biology 2008;9(2):R41-R41.</p><p>Published online 22 Feb 2008</p><p>PMCID:PMC2374700.</p><p>