Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners-9

Ons of p53 represented in structure complexes in PDB are represented by horizontal bars, labeled with the name of the binding partner. For the DBD, the extent of the globular domain is indicated by the light grey box, where the internal horizontal bars indicate regions involved in binding to a particular partner. Post translational modifications sites are represented by vertical ticks. Experimentally characterized regions of disorder (red) and order (blue) are indicated by the horizontal bar. Finally, predictions of disorder (scores > 0.5) and order (scores < 0.5) are shown for two PONDR predictors: VLXT (solid line) and VSL2P (dashed line). All, features are presented to scale, as indicated by the horizontal axis. The p53 interaction partners and post translational modification sites have been adapted from Anderson & Appella [].<p><b>Copyright information:</b></p><p>Taken from "Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners"</p><p>http://www.biomedcentral.com/1471-2164/9/S1/S1</p><p>BMC Genomics 2008;9(Suppl 1):S1-S1.</p><p>Published online 20 Mar 2008</p><p>PMCID:PMC2386051.</p><p>