P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis-3

Er immunization. At this time, the 3 WT mice all had clinical signs of 2.0; and the 3 P2x7 null mice had no clinical signs. Sections were stained with antibody SMI32 (for non phosphorylated neurofilament proteins, ) or to GFAP (, ). Representative images show significant SMI32 staining in an area of the cerebellum from WT (, ) mice, but little staining in a comparable area from P2x7 null (, ) mice. Size bars are 100 μM (, ) and 50 μm (). GFAP staining (, ) illustrates the differences in localization for GFAP and SMI32 staining. Asterisks and arrows are placed to indicate same location in images. ML, molecular layer; PL, Purkinje cell layer; GL, granule cell layer.<p><b>Copyright information:</b></p><p>Taken from "P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis"</p><p>http://www.jneuroinflammation.com/content/5/1/33</p><p>Journal of Neuroinflammation 2008;5():33-33.</p><p>Published online 8 Aug 2008</p><p>PMCID:PMC2518548.</p><p>