A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism-1

Fining the first transcription start site (S1) as +1 and a second transcription start site (S2) as −87. The approximate locations of the FNR and ModE binding sites are indicated with filled boxes, and the region designated as the Moco RNA motif begins and ends with the terminal nucleotides of P1 (). Numbering system and locations of various features are as reported previously (). B. Pathway for molybdenum cofactor biosynthesis in eubacteria (). Proteins with abbreviated designations are enzymes in the pathway except for ModABC, which is an ABC-type molybdate transporter. The precise function of MoaB is unknown, but structural studies (; ) indicate that it is similar to MogA and therefore is likely to be involved in molybdopterin biosynthesis. Question marks indicate that the biosynthetic enzymes for the conversion are not known. Other proteins listed are enzymes that use Moco derivatives as coenzymes. Proteins whose coding regions are located downstream and near a Moco RNA motif in at least one organism are highlighted with black shading.<p><b>Copyright information:</b></p><p>Taken from "A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism"</p><p></p><p>Molecular Microbiology 2008;68(4):918-932.</p><p>Published online Jan 2008</p><p>PMCID:PMC2408646.</p><p>© 2008 The Authors Journal compilation © 2008 Blackwell Publishing