Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model-2

K exposure to MDA did not affect the size of endpoint tumour burden relative to MDA-CC. () MDA or AH exposure during primary tumour development did not increase macroscopic lung metastases relative to their respective controls. () A trend towards an increased number of micrometastases was seen following MDA consumption. Micrometastases were not assessed in the hypoxia experiment due to a large number of macroscopic metastases. Abbreviations: MDA = malondialdehyde (n = 28) and MDA-CC = cage controls for MDA group (n = 30), 81 days; AH = acute hypoxia (n = 24), AC = air control (n = 26) and CC = cage controls for AH group (n = 20), 88 days. Bars: mean with SEM (A), medians (B and C). Number of animals used for each group is indicated in parentheses.<p><b>Copyright information:</b></p><p>Taken from "Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model"</p><p>http://www.biomedcentral.com/1471-2407/8/151</p><p>BMC Cancer 2008;8():151-151.</p><p>Published online 28 May 2008</p><p>PMCID:PMC2427038.</p><p>