Point at the position of its peak. The points are color coded according to the (root mean square) distance from the real data (blue, best fit; brown-black, worst fit), and clearly show the clustering of the best-fit distributions in one region of the graph. X-axis: transcript copy number for a gene; y-axis: the number of genes with a given transcript copy number.<p><b>Copyright information:</b></p><p>Taken from "Modelling and measuring single cell RNA expression levels find considerable transcriptional differences among phenotypically identical cells"</p><p>http://www.biomedcentral.com/1471-2164/9/268</p><p>BMC Genomics 2008;9():268-268.</p><p>Published online 3 Jun 2008</p><p>PMCID:PMC2429916.</p><p></p
Biological tissues are made up of many individual cells that perform different tasks in concert to c...
<p>(<b>A</b>) Overall strategy. (<b>B</b>) Validation of the primer pairs used to quantify gene expr...
Cells are the basic units of life. Studying complex tissues and whole organs requires an understandi...
Tions and compared to observed data. The experimental log intensity ratio distribution (broad green ...
By the half-vs-half (split-cell) simulations (curves with data points shown), and compared to actual...
S is shown. Numbers in the table indicate the Spearman correlation coefficients between expression l...
E-Carlo simulation of half-vs-half microarray data, based on transcript distributions and estimation...
total RNA (A) and from two dye-swapped split cell (half-vs-half) hybridizations (B). See below for f...
Phenotypically identical cells demonstrate predictable, robust behaviours. However, there is uncerta...
<p>A) <b>The same cell types</b>: Left panels: a near-unity Pearson correlation, <i>r</i>, in whole ...
Thesis (Ph.D.)--University of Washington, 2016-06This dissertation describes a set of statistical me...
RNA-Sequencing (RNA-Seq) has enabled detailed unbiased profiling of whole transcriptomes with incred...
Recent technological breakthroughs in single-cell RNA sequencing are revolutionizing modern experime...
RNA-Sequencing (RNA-Seq) has enabled detailed unbiased profiling of whole transcriptomes with incred...
Estimating the statistics of single-cell RNA numbers has become a key source of information on gene ...
Biological tissues are made up of many individual cells that perform different tasks in concert to c...
<p>(<b>A</b>) Overall strategy. (<b>B</b>) Validation of the primer pairs used to quantify gene expr...
Cells are the basic units of life. Studying complex tissues and whole organs requires an understandi...
Tions and compared to observed data. The experimental log intensity ratio distribution (broad green ...
By the half-vs-half (split-cell) simulations (curves with data points shown), and compared to actual...
S is shown. Numbers in the table indicate the Spearman correlation coefficients between expression l...
E-Carlo simulation of half-vs-half microarray data, based on transcript distributions and estimation...
total RNA (A) and from two dye-swapped split cell (half-vs-half) hybridizations (B). See below for f...
Phenotypically identical cells demonstrate predictable, robust behaviours. However, there is uncerta...
<p>A) <b>The same cell types</b>: Left panels: a near-unity Pearson correlation, <i>r</i>, in whole ...
Thesis (Ph.D.)--University of Washington, 2016-06This dissertation describes a set of statistical me...
RNA-Sequencing (RNA-Seq) has enabled detailed unbiased profiling of whole transcriptomes with incred...
Recent technological breakthroughs in single-cell RNA sequencing are revolutionizing modern experime...
RNA-Sequencing (RNA-Seq) has enabled detailed unbiased profiling of whole transcriptomes with incred...
Estimating the statistics of single-cell RNA numbers has become a key source of information on gene ...
Biological tissues are made up of many individual cells that perform different tasks in concert to c...
<p>(<b>A</b>) Overall strategy. (<b>B</b>) Validation of the primer pairs used to quantify gene expr...
Cells are the basic units of life. Studying complex tissues and whole organs requires an understandi...