Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach-5

Rythrocyte CaCaATPase, skeletal Myosin Light Chain Kinase (skMLCK) (A). (B) and (C) show the Cabinding to CaM in the presence of parts of skMLCK and CaATPase peptides, respectively [33]. Interaction data for Ca-CaM complexes in the presence and absence of protein kinase II (CaMPKII) reveal parameters of complex formation reaction [49]. The solid line in each case shows the model prediction for Ca-CaM binding. is macroscopic Cadissociation constant, is the cooperatively affected dissociation constants. Arrows indicate the number of Caions bound to CaM required to create a complex with a target molecule peptide.<p><b>Copyright information:</b></p><p>Taken from "Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach"</p><p>http://www.biomedcentral.com/1752-0509/2/48</p><p>BMC Systems Biology 2008;2():48-48.</p><p>Published online 2 Jun 2008</p><p>PMCID:PMC2435525.</p><p>