Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat-2

S sedimentation coefficient distribution C(S) of tubulin (5 μM) in the absence (black solid line), or in the presence of 10 μM holo-Tat (blue dashed line) or 10 μM apo-Tat (red dotted line). Inset: Full range C(S) of tubulin (5 μM) in the presence of 10 μM apo-Tat (red dotted line). Tat contributed to less than 10% of the signal. B. Electron micrograph of 5 μM tubulin in the presence of 10 μM apo-Tat, in PG buffer.<p><b>Copyright information:</b></p><p>Taken from "Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat"</p><p>http://www.retrovirology.com/content/5/1/62</p><p>Retrovirology 2008;5():62-62.</p><p>Published online 9 Jul 2008</p><p>PMCID:PMC2483996.</p><p>