(A) Real-time quantitative PCR analysis showing that gene expression levels of 1α-hydroxylase from kidney tissues of mice is much higher than those of wild-type (control) mice

Graphs represent mean ± SD (kidney, = 6; intestine, = 5 ). *, P < 0.01. (B and C) TUNEL staining of tissue sections from kidney and intestine of mice showing far higher levels of apoptosis than those of wild-type mice. double knockout mice show a complete rescue of the apoptosis seen in tissues of mice. Bar, 100 μm. Graphs represent mean ± SD ( = 3). *, P < 0.001.<p><b>Copyright information:</b></p><p>Taken from "FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis"</p><p></p><p>The Journal of Cell Biology 2008;182(3):459-465.</p><p>Published online 11 Aug 2008</p><p>PMCID:PMC2500132.</p><p>