Structure of the Abl kinase in complex with imatinib (red, left panel), dasatinib (red, middle panel), and MK-0457 (red, right panel)

The positions of the P-loop and the activation loop are indicated in yellow. Imatinib binds and stabilizes the inactive conformation of Abl (left panel) whereas dasatinib binds to the active conformation of the Abl kinase which is similar for Src and Abl (middle panel). MK-0457 (left panel) is not fully buried in the kinase domain and is anchored to this domain by 4 hydrogen bonds to sequence-invariant elements within the active form of Abl. Derived from , , and .<p><b>Copyright information:</b></p><p>Taken from "Therapeutic options for chronic myeloid leukemia: focus on imatinib (Glivec, Gleevec™)"</p><p></p><p>Therapeutics and Clinical Risk Management 2008;4(1):163-187.</p><p>Published online Jan 2008</p><p>PMCID:PMC2503652.</p><p>© 2008 Dove Medical Press Limited. All rights reserved