The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia-2

<p><b>Copyright information:</b></p><p>Taken from "The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia"</p><p>Journal of Neuroinflammation 2007;4():15-15.</p><p>Published online 5 Jun 2007</p><p>PMCID:PMC1892010.</p><p></p>ative doses of gabapentin in normal (A), arthritic (B) and neuropathic animals (C). The units were activated in three minute cycles by 10 s of noxious mechanical stimulation and 16 electrical pulses (2 ms pulse width, 1 Hz and twice the threshold intensity for the recruitment of C-fibers). Gabapentin was administered iv. in log2 cumulative doses every three cycles of stimulation (9 minutes) from 40 to 1,280 μmol/kg (7 to 224 mg/kg). The administration of gabapentin dose-dependently reduced the nociceptive responses in arthritic and neuropathic animals but not in normal rats