Dose dependent suppression of disease activity of collagen-induced arthritis (CIA) by interleukin (IL)-4 and the combination of IL-4/prednisolone (Pred)

<p><b>Copyright information:</b></p><p>Taken from "Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis"</p><p>Arthritis Research 1999;1(1):81-91.</p><p>Published online 26 Oct 1999</p><p>PMCID:PMC17779.</p><p>Copyright © 1999 Current Science Ltd</p> Mice with established CIA were divided into separate groups of at least 10 mice. Groups were treated intraperitoneally twice a day with vehicle, IL-4, prednisolone, or combined IL-4/prednisolone for 8 consecutive days. The data represent the mean arthritis score, expressed as percentage of initial value at day 28. Experiments were repeated once with approximately the same outcome. * < 0.05, versus vehicle, by Mann-Whitney U test