Reduced migration and increased differentiation of keratinocytes in K5-GR wounds relative to K5-GR-TR and WT mice.

<p>Skin wounds were collected from WT, K5-GR or K5-GR-TR mice at d4 and d8 to evaluate the expression of K6 and K10 by immunostaining using specific antibodies. Representative results from 5 mice of each genotype are shown. The arrow indicates the migrating tip of the WT wound and the asterisks indicate the impaired keratinocyte migration in the transgenics. Boxed areas are enlarged. Higher magnification of boxed areas is at the lower right of each image. Bar: 100 µm.