Spatial agreement between functional and anatomical connectivity maps.

<p>The figure demonstrates spatial overlap, within the putamen or thalamus, between the areas reached by white matter nigral projections and the resting-state functional activations of the substantia nigra. The white wireframe volumes represent reconstructions of the nigrostriatal (A) and nigrothalamic (B) pathways. R-fMRI activation maps of the substantia nigra were obtained using FDR (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029153#s4" target="_blank">Materials and Methods</a>). They are represented using isolines of equal p-values, with blue lines corresponding to p = 0.01 and red lines to p≪0.01. Spatial agreement between anatomical and functional connectivity maps is visible in the dorsal part of the putamen (A) and in thalamus, within the putative Vc nucleus (B). Orientation in (A) is caudo-rostral with T2-weighted image at the level of the substantia nigra. Inset in (A) is a magnified view of the overlap area between anatomical and functional connectivity. The red surface representing putamen was clipped in its upper part to reveal the R-fMRI activation (isolines) and endpoint of the nigrostriatal projections. Orientation in (B) is oblique caudo-rostral with SWI images at the level of the inferior and anterior thalamus.