<p>Time for the active form (TR*) to reach a threshold is registered versus the time difference between transcriptional initiation of the activator (green) or inhibitor (red). Rectangles show averages, shaded backgrounds show ± standard deviations from 1000 simulations at a given transcriptional advance (negative values on x-axis) or delay (positive values) compared to TR transcription.</p
Actb_result_ACF_fitting: Results of the steady-state autocorrelation method from Actb gene. Actb_r...
<p>Sign indicates whether feedback input arrives before (negative value) or after (positive values) ...
<p>(<b>A</b>) Numerical simulations showing the effect of increasing feedback gain on the magnitude ...
<p>(A) Density plot for 100,000 simulation results at each time point from 0 to 60 minutes for trans...
<p>(A) For the simplified symmetric distribution where the delay takes values and with equal proba...
<p>(a) Schematic of the dual E2F1 reporter constructs. (b) Metrics to quantify the two types of dyna...
<p>The plots show the expression of a gene (blue) controlled by the symmetric signal (black) for t...
<p>a) Template D167. b) Template D387. Each column represents the reaction time for that simulation....
<p>A) Correlation matrix between time points for mRNA abundance (RA) and transcription rate (TR) ana...
<p>The lines and discrete dots correspond to analytical results and MC simulations, respectively. Th...
<p><i>x</i>-Axis indicates interval between start of induction and maintenance therapies, in days. M...
<p>The figure shows the estimation of transcriptional time lag. In this example, with respect to the...
<p>Delayed gains were computed as the difference in errors and speed between T3 and T2, and then nor...
(A) Three representative pie charts of fractional promoter-state probability of UP (blue), AP (teal)...
<p>We tested how extrinsic parameter variations in the regulation of the transcriptionally controlle...
Actb_result_ACF_fitting: Results of the steady-state autocorrelation method from Actb gene. Actb_r...
<p>Sign indicates whether feedback input arrives before (negative value) or after (positive values) ...
<p>(<b>A</b>) Numerical simulations showing the effect of increasing feedback gain on the magnitude ...
<p>(A) Density plot for 100,000 simulation results at each time point from 0 to 60 minutes for trans...
<p>(A) For the simplified symmetric distribution where the delay takes values and with equal proba...
<p>(a) Schematic of the dual E2F1 reporter constructs. (b) Metrics to quantify the two types of dyna...
<p>The plots show the expression of a gene (blue) controlled by the symmetric signal (black) for t...
<p>a) Template D167. b) Template D387. Each column represents the reaction time for that simulation....
<p>A) Correlation matrix between time points for mRNA abundance (RA) and transcription rate (TR) ana...
<p>The lines and discrete dots correspond to analytical results and MC simulations, respectively. Th...
<p><i>x</i>-Axis indicates interval between start of induction and maintenance therapies, in days. M...
<p>The figure shows the estimation of transcriptional time lag. In this example, with respect to the...
<p>Delayed gains were computed as the difference in errors and speed between T3 and T2, and then nor...
(A) Three representative pie charts of fractional promoter-state probability of UP (blue), AP (teal)...
<p>We tested how extrinsic parameter variations in the regulation of the transcriptionally controlle...
Actb_result_ACF_fitting: Results of the steady-state autocorrelation method from Actb gene. Actb_r...
<p>Sign indicates whether feedback input arrives before (negative value) or after (positive values) ...
<p>(<b>A</b>) Numerical simulations showing the effect of increasing feedback gain on the magnitude ...