Impact of the <i>NRGN</i> genotype on GM volume of left anterior cingulate gyrus in schizophrenia.

<p>(<b>A</b>) Anatomical localizations are displayed on coronal, sagittal, and axial sections of a normal MRI spatially normalized into the Montreal Neurological Institute template (uncorrected <i>p</i><0.001, cluster size>100). A significant cluster of the genotype effect was in the left anterior cingulate gyrus in the patients with schizophrenia, after controlling for differences in the duration of illness among genotypes. The region is shown as cross-hairline. The color bars show <i>t</i> values corresponding to the color in the figure. (<b>B</b>) Each column shows relative gray matter volumes extracted from the left anterior cingulate gyrus (Talairach coordinates; −12, 42, −9). We extracted a sphere with a 10 mm volume-of-interest (VOI) radius from the significant region to compare the effects of the genotype in both the patients with schizophrenia and healthy subjects. Error bars represent the standard error.