Compounds discovered in the spleen qHTS tested for modulation of GCase activity and GCase translocation in cell assays.

Cell viability, cellular uptake, and mitochondrial membrane potential changes following exposure to GNPs.

Sherleen Xue-Fu Adamson (5942870)
Ruoxing Wang (1878172)
Wenzhuo Wu (1454755)
Bruce Cooper (151851)
Jonathan Shannahan (2848196)

November 2018

(A). Cell viability percentages of macrophages following the exposure to 0, 25, 50, or 100 μg/mL GNP...

GCase protein levels in diltiazem-treated cultured fibroblasts.

Ying Sun (23237)
Benjamin Liou (353035)
Brian Quinn (353037)
Huimin Ran (353034)
You-Hai Xu (364882)
Gregory A. Grabowski (353044)

February 2013

(A) Immunoblot of mouse GCase and β-actin protein in diltiazem (12.5 µM) treated and untreated WT...

Associations with F are altered by O-glycan loss.

Jacquelyn A. Stone (488032)
Anthony V. Nicola (442558)
Linda G. Baum (245676)
Hector C. Aguilar (245661)

February 2016

A) Cell lysates of cells transfected with wt F and either wt or mutant HeV G. HeV G (top) is blot...

Dose response increase in lysosomal content of GCase in fibroblasts treated with selected identified compounds.

Ehud Goldin (187614)
Wei Zheng (25452)
Omid Motabar (187620)
Noel Southall (187625)
Jae Hyuk Choi (187629)
Juan Marugan (187635)
Christopher P. Austin (85106)
Ellen Sidransky (18202)

January 2012

Cells were treated with six drug concentrations (1 nM to 50 µM) for 5 days. The intensity of GCas...

Concentration responses of three GCase inhibitors determined using recombinant WT GCase, recombinant N370S mutant enzyme, WT GCase from normal spleen extract and N370S mutant enzyme from a spleen of a patient with GD (genotype N370S/N370S).

Ehud Goldin (187614)
Wei Zheng (25452)
Omid Motabar (187620)
Noel Southall (187625)
Jae Hyuk Choi (187629)
Juan Marugan (187635)
Christopher P. Austin (85106)
Ellen Sidransky (18202)

January 2012

The three inhibitors were identified from the previous HTS using recombinant WT GCase.</p

GCase activity and protein.

Ying Sun (23237)
Huimin Ran (353034)
Benjamin Liou (353035)
Brian Quinn (353037)
Matt Zamzow (353039)
Wujuan Zhang (353041)
Jacek Bielawski (251333)
Kazuyuki Kitatani (353042)
Kenneth D. R. Setchell (275564)
Yusuf A. Hannun (116276)
Gregory A. Grabowski (353044)

February 2013

(A) GCase activity was significantly increased in the treated 4L;C* liver by 3-fold in 20 mg/kg/d...

GlyT2 expression after a pulse-chased in culture cells.

Esther Arribas-González (409128)
Pablo Alonso-Torres (409129)
Carmen Aragón (386086)
Beatriz López-Corcuera (386085)

May 2013

COS7 cells transfected with GlyT2 cDNA in pCDNA3 were pulse-labeled for 15 min with [35</sup...

Translocation of glucose transporters GLUT4 in the plasma membrane upon activation of P2Y6R.

Ramachandran Balasubramanian (680034)
Bernard Robaye (297896)
Jean-Marie Boeynaems (82311)
Kenneth A. Jacobson (117993)

December 2014

(A) Immunoblotting is used to determine the changes in the membrane levels of the GLUT4 transport...

CD4+ cells migrate to the spleen and CD8+ cells migrate to the thymus.

Lisa J. Ma (376126)
Barbara Walter (72556)
Ariel DeGuzman (376127)
H. Konrad Muller (376128)
Ameae M. Walker (376129)

February 2013

RT-PCR for GFP at weekly time points and FACS analysis of cells positive for GFP and an additiona...

Multiple Functions of Glutathione Transferases : A Study on Enzymatic Function, Regulatory Role and Distribution in Mouse and Man

Edalat, Maryam

January 2002

To cope with various endogenous toxin and xenobiotics nature has equipped the organisms with a prope...

Chymase promotes cytoplasmic translocation of NR4A1 in HL-1 cells.

Junying Zheng (154714)
Chih-Chang Wei (117683)
Naoki Hase (551884)
Ke Shi (154717)
Cheryl R. Killingsworth (551885)
Silvio H. Litovsky (412429)
Pamela C. Powell (154722)
Tsunefumi Kobayashi (551886)
Carlos M. Ferrario (154728)
Andras Rab (551887)
Inmaculada Aban (551888)
James F. Collawn (551889)
Louis J. Dell'Italia (551890)

April 2014

Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 ...

Release and uptake of lysosomal enzymes : studied in cultured cells

Halley, Dicky

June 1980

textabstractThe purpose of the experimental work described in this thesiswas to investigate some asp...

Ig class switching and proliferation of splenic B cells are not reduced in glycosylase-deficient mice.

Anna J. Ucher (325599)
Erin K. Linehan (325600)
George W. Teebor (325601)
Carol E. Schrader (325602)
Janet Stavnezer (325603)

February 2013

(A) Splenic B cell proliferation as assayed by dilution of CFSE assayed ∼44 hrs after treatment t...

Chemical agents and enzymes used for the extraction of gut lymphocytes influence flow cytometric detection of T cell surface markers.

Van Damme, Nicole
Baeten, D
De Vos, Marc
Demetter, Pieter
Elewaut, D
Mielants, H
Verbruggen, G
Cuvelier, Claude A
Veys, E M
De Keyser, Frédérique

March 2000

Chemical agents (DTT, EDTA) and enzymes (collagenase, DNAse) are often used for the generation of a ...

Nuclear localization of GNL3L promotes ‘S’ phase progression.

Indu Jose Thoompumkal (783764)
Malireddi Rama Krishna Subba Rao (783765)
Anbarasu Kumaraswamy (783766)
Rehna Krishnan (783767)
Sundarasamy Mahalingam (783768)

August 2015

HEK293 (A) and MCF-7 (B) cells were transfected with wild type or indicated variant...

Cell viability, cellular uptake, and mitochondrial membrane potential changes following exposure to GNPs.

Sherleen Xue-Fu Adamson (5942870)
Ruoxing Wang (1878172)
Wenzhuo Wu (1454755)
Bruce Cooper (151851)
Jonathan Shannahan (2848196)

November 2018

(A). Cell viability percentages of macrophages following the exposure to 0, 25, 50, or 100 μg/mL GNP...

GCase protein levels in diltiazem-treated cultured fibroblasts.

Ying Sun (23237)
Benjamin Liou (353035)
Brian Quinn (353037)
Huimin Ran (353034)
You-Hai Xu (364882)
Gregory A. Grabowski (353044)

February 2013

(A) Immunoblot of mouse GCase and β-actin protein in diltiazem (12.5 µM) treated and untreated WT...

Associations with F are altered by O-glycan loss.

Jacquelyn A. Stone (488032)
Anthony V. Nicola (442558)
Linda G. Baum (245676)
Hector C. Aguilar (245661)

February 2016

A) Cell lysates of cells transfected with wt F and either wt or mutant HeV G. HeV G (top) is blot...

Dose response increase in lysosomal content of GCase in fibroblasts treated with selected identified compounds.

Ehud Goldin (187614)
Wei Zheng (25452)
Omid Motabar (187620)
Noel Southall (187625)
Jae Hyuk Choi (187629)
Juan Marugan (187635)
Christopher P. Austin (85106)
Ellen Sidransky (18202)

January 2012

Cells were treated with six drug concentrations (1 nM to 50 µM) for 5 days. The intensity of GCas...

Concentration responses of three GCase inhibitors determined using recombinant WT GCase, recombinant N370S mutant enzyme, WT GCase from normal spleen extract and N370S mutant enzyme from a spleen of a patient with GD (genotype N370S/N370S).

Ehud Goldin (187614)
Wei Zheng (25452)
Omid Motabar (187620)
Noel Southall (187625)
Jae Hyuk Choi (187629)
Juan Marugan (187635)
Christopher P. Austin (85106)
Ellen Sidransky (18202)

January 2012

The three inhibitors were identified from the previous HTS using recombinant WT GCase.</p

GCase activity and protein.

Ying Sun (23237)
Huimin Ran (353034)
Benjamin Liou (353035)
Brian Quinn (353037)
Matt Zamzow (353039)
Wujuan Zhang (353041)
Jacek Bielawski (251333)
Kazuyuki Kitatani (353042)
Kenneth D. R. Setchell (275564)
Yusuf A. Hannun (116276)
Gregory A. Grabowski (353044)

February 2013

(A) GCase activity was significantly increased in the treated 4L;C* liver by 3-fold in 20 mg/kg/d...

GlyT2 expression after a pulse-chased in culture cells.

Esther Arribas-González (409128)
Pablo Alonso-Torres (409129)
Carmen Aragón (386086)
Beatriz López-Corcuera (386085)

May 2013

COS7 cells transfected with GlyT2 cDNA in pCDNA3 were pulse-labeled for 15 min with [35</sup...

Translocation of glucose transporters GLUT4 in the plasma membrane upon activation of P2Y6R.

Ramachandran Balasubramanian (680034)
Bernard Robaye (297896)
Jean-Marie Boeynaems (82311)
Kenneth A. Jacobson (117993)

December 2014

(A) Immunoblotting is used to determine the changes in the membrane levels of the GLUT4 transport...

CD4+ cells migrate to the spleen and CD8+ cells migrate to the thymus.

Lisa J. Ma (376126)
Barbara Walter (72556)
Ariel DeGuzman (376127)
H. Konrad Muller (376128)
Ameae M. Walker (376129)

February 2013

RT-PCR for GFP at weekly time points and FACS analysis of cells positive for GFP and an additiona...

Multiple Functions of Glutathione Transferases : A Study on Enzymatic Function, Regulatory Role and Distribution in Mouse and Man

Edalat, Maryam

January 2002

To cope with various endogenous toxin and xenobiotics nature has equipped the organisms with a prope...

Chymase promotes cytoplasmic translocation of NR4A1 in HL-1 cells.

Junying Zheng (154714)
Chih-Chang Wei (117683)
Naoki Hase (551884)
Ke Shi (154717)
Cheryl R. Killingsworth (551885)
Silvio H. Litovsky (412429)
Pamela C. Powell (154722)
Tsunefumi Kobayashi (551886)
Carlos M. Ferrario (154728)
Andras Rab (551887)
Inmaculada Aban (551888)
James F. Collawn (551889)
Louis J. Dell'Italia (551890)

April 2014

Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 ...

Release and uptake of lysosomal enzymes : studied in cultured cells

Halley, Dicky

June 1980

textabstractThe purpose of the experimental work described in this thesiswas to investigate some asp...

Ig class switching and proliferation of splenic B cells are not reduced in glycosylase-deficient mice.

Anna J. Ucher (325599)
Erin K. Linehan (325600)
George W. Teebor (325601)
Carol E. Schrader (325602)
Janet Stavnezer (325603)

February 2013

(A) Splenic B cell proliferation as assayed by dilution of CFSE assayed ∼44 hrs after treatment t...

Chemical agents and enzymes used for the extraction of gut lymphocytes influence flow cytometric detection of T cell surface markers.

Van Damme, Nicole
Baeten, D
De Vos, Marc
Demetter, Pieter
Elewaut, D
Mielants, H
Verbruggen, G
Cuvelier, Claude A
Veys, E M
De Keyser, Frédérique

March 2000

Chemical agents (DTT, EDTA) and enzymes (collagenase, DNAse) are often used for the generation of a ...

Nuclear localization of GNL3L promotes ‘S’ phase progression.

Indu Jose Thoompumkal (783764)
Malireddi Rama Krishna Subba Rao (783765)
Anbarasu Kumaraswamy (783766)
Rehna Krishnan (783767)
Sundarasamy Mahalingam (783768)

August 2015

HEK293 (A) and MCF-7 (B) cells were transfected with wild type or indicated variant...

Cell viability, cellular uptake, and mitochondrial membrane potential changes following exposure to GNPs.

Sherleen Xue-Fu Adamson (5942870)
Ruoxing Wang (1878172)
Wenzhuo Wu (1454755)
Bruce Cooper (151851)
Jonathan Shannahan (2848196)

November 2018

(A). Cell viability percentages of macrophages following the exposure to 0, 25, 50, or 100 μg/mL GNP...

GCase protein levels in diltiazem-treated cultured fibroblasts.

Ying Sun (23237)
Benjamin Liou (353035)
Brian Quinn (353037)
Huimin Ran (353034)
You-Hai Xu (364882)
Gregory A. Grabowski (353044)

February 2013

(A) Immunoblot of mouse GCase and β-actin protein in diltiazem (12.5 µM) treated and untreated WT...

Associations with F are altered by O-glycan loss.

Jacquelyn A. Stone (488032)
Anthony V. Nicola (442558)
Linda G. Baum (245676)
Hector C. Aguilar (245661)

February 2016

A) Cell lysates of cells transfected with wt F and either wt or mutant HeV G. HeV G (top) is blot...

Compounds discovered in the spleen qHTS tested for modulation of GCase activity and GCase translocation in cell assays.

Abstract

Extracted data

Compounds discovered in the spleen qHTS tested for modulation of GCase activity and GCase translocation in cell assays.

Abstract

Extracted data

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