Correlation between RU486-induced PR-binding and RU486-mediated gene expression.

<p>Venn diagrams summarize the number of RU486-mediated genes with identified PR-binding sites within 5 kb from their TSSs in breast cancer cells (A) and leiomyoma cells (B). Distribution of PR-binding sites relative to TSSs of differentially expressed genes in T47D breast cancer cells (C) and uterine leiomyoma cells (D). T47D and leiomyoma cells were treated with vehicle (ethanol) or RU486 (10⁻⁶ M) for 6 hours and expression profiling was performed using Human HT-12 v4 Expression BeadChip arrays from Illumina. The percentage of all differentially regulated genes with PR-binding sites in each region is shown in the vertical axis. The distance relative to the TSS is shown in the horizontal axis.