Top drug and complex hubs in the bipartite protein complex – drug network.
- Jose C. Nacher (187435)
- Jean-Marc Schwartz (48178)
Publication date
January 2012
DOIAbstract
<p>Top drug and complex hubs in the bipartite protein complex – drug network.</p
<p>Top drug and complex hubs in the bipartite protein complex – drug network.</p
The pharmacological networks for (A) cross-validation targets; (B) cross-validation targets in the p...
<p>The green nodes and blue nodes are proteins identified by <i>DC</i>; the former are true essentia...
<p>A) Drug name and number of high correlated genes mapped from the human PHEO and the murine MTT mi...
<p>A drug is connected to a protein complex if at least one protein target of the drug is also a sub...
<p>Each module of the protein complex – drug bipartite network was shrunk into a node and the drug p...
<p>Links between the disease node and protein complexes represent associations between genes involve...
<p>Links between the disease node and protein complexes represent associations between genes involve...
<p>In the figure, a diamond node represents a hub protein, and a hexagon node represents a hub and b...
Recent studies have highlighted the importance of interconnectivity in a large range of molecular an...
<p>Green, the five compounds from BZ; Pink, the target-associated genes; Yellow, the shared genes am...
<p>(a) A bipartite sub-network extracted from the complex-drug network. (b) The drug and protein com...
<p>BQC Network 1 Drug Metabolism, Molecular Transport, Nucleic Acid Metabolism.</p
<p>The P-value was evaluated by the significance of overlap between the hub genes and drug targets. ...
<p>Figures A and B show the top 10 highest ranked hubs identified by BN and DSS methods, respectivel...
<p>Here “Total” denotes the statistics of each reference database which are not mapped into a specia...
The pharmacological networks for (A) cross-validation targets; (B) cross-validation targets in the p...
<p>The green nodes and blue nodes are proteins identified by <i>DC</i>; the former are true essentia...
<p>A) Drug name and number of high correlated genes mapped from the human PHEO and the murine MTT mi...
<p>A drug is connected to a protein complex if at least one protein target of the drug is also a sub...
<p>Each module of the protein complex – drug bipartite network was shrunk into a node and the drug p...
<p>Links between the disease node and protein complexes represent associations between genes involve...
<p>Links between the disease node and protein complexes represent associations between genes involve...
<p>In the figure, a diamond node represents a hub protein, and a hexagon node represents a hub and b...
Recent studies have highlighted the importance of interconnectivity in a large range of molecular an...
<p>Green, the five compounds from BZ; Pink, the target-associated genes; Yellow, the shared genes am...
<p>(a) A bipartite sub-network extracted from the complex-drug network. (b) The drug and protein com...
<p>BQC Network 1 Drug Metabolism, Molecular Transport, Nucleic Acid Metabolism.</p
<p>The P-value was evaluated by the significance of overlap between the hub genes and drug targets. ...
<p>Figures A and B show the top 10 highest ranked hubs identified by BN and DSS methods, respectivel...
<p>Here “Total” denotes the statistics of each reference database which are not mapped into a specia...
The pharmacological networks for (A) cross-validation targets; (B) cross-validation targets in the p...
<p>The green nodes and blue nodes are proteins identified by <i>DC</i>; the former are true essentia...
<p>A) Drug name and number of high correlated genes mapped from the human PHEO and the murine MTT mi...
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