<p> The paralytic response to aldicarb treatment was analyzed in strains containing mutations that inactivate pro-neuropeptide processing enzymes (<i>egl-3</i> PC2 and <i>egl-21</i> CPE), or those inactivating RIC-7. The number of trials (∼20 animals/trial) is shown for each genotype. Values that differ significantly from wild type (*, p<0.01; **, p<0.001, Students t-test) are indicated. Error bars indicate SEM. Values that are not significantly different are indicated (ns).</p
<p>Phenotypes measured after 72 h of drug exposure that significantly differed across individuals (A...
<p>For each variant the relative activity at Aβ divided by the relative activity on the off target p...
<p>(A–B). Convulsion frequencies of <i>acr-2(gf)</i> combined with loss of function mutations in <i>...
For mutant alleles tested for aldicarb sensitivity see Table S1. Alleles used for aldicarb resistant...
<p>The choline acetyltransferase gene <i>cha-1</i> was specifically knocked down by RNAi in the SIA ...
<p><i>cat-2;crh-1</i> mutants were transformed with <i>ceh-17::crh-1</i> and the co-injection marker...
(A) The drug aldicarb inhibits acetylcholinesterase and leads to acetylcholine build-up at the neuro...
<p>Double mutants for <i>cat-2</i> and <i>tbh-1</i> (A), <i>ser-3</i> (B), or <i>crh-1</i> (C) were ...
<p>Levels of ACh secretion were assayed by following the time course of paralysis of animals on 1 mM...
<p>(A) Cholinergic neuronal transmission was measured by determining the onset of paralysis induced ...
<p>Rates of worm paralysis of the indicated strains when exposed to aldicarb. (A) Expression of WDR-...
<p>Down-regulation of the EH-interactors was achieved by feeding RNA interference (RNAi), in the ind...
<p>250 samples from 234 drug-naive patients and 115 samples from 78 treated A/AE patients were genot...
<p>(A) Convulsion frequency of <i>acr-2(gf)</i> in combination with loss of function (lf) mutations ...
<p>Null <i>unc-18</i> (<i>e81</i>) worms were rescued transgenically with wild-type (Wt) <i>unc-18</...
<p>Phenotypes measured after 72 h of drug exposure that significantly differed across individuals (A...
<p>For each variant the relative activity at Aβ divided by the relative activity on the off target p...
<p>(A–B). Convulsion frequencies of <i>acr-2(gf)</i> combined with loss of function mutations in <i>...
For mutant alleles tested for aldicarb sensitivity see Table S1. Alleles used for aldicarb resistant...
<p>The choline acetyltransferase gene <i>cha-1</i> was specifically knocked down by RNAi in the SIA ...
<p><i>cat-2;crh-1</i> mutants were transformed with <i>ceh-17::crh-1</i> and the co-injection marker...
(A) The drug aldicarb inhibits acetylcholinesterase and leads to acetylcholine build-up at the neuro...
<p>Double mutants for <i>cat-2</i> and <i>tbh-1</i> (A), <i>ser-3</i> (B), or <i>crh-1</i> (C) were ...
<p>Levels of ACh secretion were assayed by following the time course of paralysis of animals on 1 mM...
<p>(A) Cholinergic neuronal transmission was measured by determining the onset of paralysis induced ...
<p>Rates of worm paralysis of the indicated strains when exposed to aldicarb. (A) Expression of WDR-...
<p>Down-regulation of the EH-interactors was achieved by feeding RNA interference (RNAi), in the ind...
<p>250 samples from 234 drug-naive patients and 115 samples from 78 treated A/AE patients were genot...
<p>(A) Convulsion frequency of <i>acr-2(gf)</i> in combination with loss of function (lf) mutations ...
<p>Null <i>unc-18</i> (<i>e81</i>) worms were rescued transgenically with wild-type (Wt) <i>unc-18</...
<p>Phenotypes measured after 72 h of drug exposure that significantly differed across individuals (A...
<p>For each variant the relative activity at Aβ divided by the relative activity on the off target p...
<p>(A–B). Convulsion frequencies of <i>acr-2(gf)</i> combined with loss of function mutations in <i>...