RITA induces activation of JNK signaling in MM cells.

<p>(A) H929 and MM.1S cells (harboring wild type p53), and (B) 8226R5 (p53 null) and U266 (p53 mutant) cell lines were treated with different concentrations of RITA for 8 hrs. (C) H929 or MM.1S cells were treated with 2.5 µM or 1 µM RITA, respectively for different time periods (4–12 hrs). The cells were then harvested and subjected to preparation of whole-cell protein lysates for detection of the indicated proteins by Western blot analysis.