Theonellasterol alters the liver expression of genes involved in bile acid metabolism in BDL mice.

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.

Barbara Renga
Andrea Mencarelli
Claudio D'Amore
Sabrina Cipriani
Maria Valeria D'Auria
Valentina Sepe
Maria Giovanna Chini
Maria Chiara Monti
Giuseppe Bifulco
Angela Zampella
Stefano Fiorucci

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastroin...

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Renga B.
Mencarelli A.
D'Amore C.
Cipriani S
D'AURIA, MARIA VALERIA
SEPE, VALENTINA
Chini M. G.
Monti M. C.
Bifulco G.
ZAMPELLA, ANGELA
Fiorucci S.

January 2012

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastroi...

Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.

Gillard, J.
Clerbaux, L.A.
Nachit, M.
Sempoux, C.
Staels, B.
Bindels, L.B.
Tailleux, A.
Leclercq, I.A.

January 2022

Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid and glucose metabolism, inflammation...

BDL causes liver cell injury and theonellasterol attenuates liver necrosis.

Barbara Renga (134135)
Andrea Mencarelli (134128)
Claudio D'Amore (134144)
Sabrina Cipriani (134132)
Maria Valeria D'Auria (186782)
Valentina Sepe (186788)
Maria Giovanna Chini (186796)
Maria Chiara Monti (186804)
Giuseppe Bifulco (186812)
Angela Zampella (186821)
Stefano Fiorucci (134151)

January 2012

(A and B) Liver necrosis was robustly attenuated by theonellasterol as confirmed by assess...

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

Renga Barbara
Mencarelli Andrea
D'Amore Claudio
Cipriani Sabrina
D'Auria Maria Valeria
Sepe Valentina
Chini Maria Giovanna
Monti Maria Chiara
Bifulco Giuseppe
Zampella Angela
Fiorucci Stefano

January 2012

. Here, we have characterized the activity of this theonellasterol on FXR-regulated genes and biolog...

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

Renga Barbara
Mencarelli Andrea
D'Amore Claudio
Cipriani Sabrina
D'Auria Maria Valeria
Sepe Valentina
Chini Maria Giovanna
Monti Maria Chiara
Bifulco Giuseppe
Zampella Angela
Fiorucci Stefano

January 2012

. Here, we have characterized the activity of this theonellasterol on FXR-regulated genes and biolog...

Bile acid genes expression differs between p53+/− and WT mice.

Francois Leblond (539482)
Steve Poirier (148055)
Carol Yu (539483)
Natacha Duquette (539484)
Gaetan Mayer (5658463)
Eric Thorin (539485)

March 2014

Hepatic mRNA expression of genes implicated in bile acid metabolism in WT and p53+/− 6...

Theonellasterol reverses the effect of CDCA on the expression of canonical FXR target genes.

Barbara Renga (134135)
Andrea Mencarelli (134128)
Claudio D'Amore (134144)
Sabrina Cipriani (134132)
Maria Valeria D'Auria (186782)
Valentina Sepe (186788)
Maria Giovanna Chini (186796)
Maria Chiara Monti (186804)
Giuseppe Bifulco (186812)
Angela Zampella (186821)
Stefano Fiorucci (134151)

January 2012

Relative mRNA expression of (A) OSTα, (B) BSEP, (C) SHP and (D) MRP4 in HepG2 cells treated with ...

Analysis of lipids and xenobiotics target genes expression in the liver.

Magali Foucaud-Vignault (343955)
Zeina Soayfane (343957)
Cécile Ménez (300702)
Justine Bertrand-Michel (76337)
Pascal Guy Pierre Martin (343960)
Hervé Guillou (343962)
Xavier Collet (76339)
Anne Lespine (300705)

February 2013

Relative gene expressions of scd-1, fasn, cd36, acox, cyp2B10 ...

Key mediators of bile acids (BA) synthesis in the liver of mice.

Francois Leblond (539482)
Steve Poirier (148055)
Carol Yu (539483)
Natacha Duquette (539484)
Gaetan Mayer (5658463)
Eric Thorin (539485)

March 2014

A) Transcription factors p53 and farnesoid X receptor (FXR) can activate the transcription of sma...

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

Barbara Renga (134135)
Andrea Mencarelli (134128)
Claudio D'Amore (134144)
Sabrina Cipriani (134132)
Maria Valeria D'Auria (186782)
Valentina Sepe (186788)
Maria Giovanna Chini (186796)
Maria Chiara Monti (186804)
Giuseppe Bifulco (186812)
Angela Zampella (186821)
Stefano Fiorucci (134151)

January 2012

<div><h3>Background</h3>The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liv...

Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet.

Kazuya Okushin
Takeya Tsutsumi
Kazuhiko Ikeuchi
Akira Kado
Kenichiro Enooku
Hidetaka Fujinaga
Naoko Yamauchi
Tetsuo Ushiku
Kyoji Moriya
Hiroshi Yotsuyanagi
Kazuhiko Koike

January 2020

The incidence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, including in Asian cou...

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Renga B.
Mencarelli A.
D'Amore C.
Cipriani S
D'AURIA, MARIA VALERIA
SEPE, VALENTINA
Chini M. G.
Monti M. C.
Bifulco G.
ZAMPELLA, ANGELA
Fiorucci S.

January 2012

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastroi...

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

Wang, Xiu Jun
Chamberlain, Mark
Vassieva, Olga
Henderson, Colin J.
Wolf, C. Roland

June 2005

Cytochrome P450 reductase is the unique electron donor for microsomal cytochrome P450s; these enzyme...

Hepatic gene expression levels significantly suppressed by β-cryptoxanthin in NASH.

Masuko Kobori (208009)
Yinhua Ni (307069)
Yumiko Takahashi (568105)
Natsumi Watanabe (568106)
Minoru Sugiura (292984)
Kazunori Ogawa (292986)
Mayumi Nagashimada (568107)
Shuichi Kaneko (156576)
Shigehiro Naito (53228)
Tsuguhito Ota (307055)

May 2014

C57BL/6J mice were fed a standard chow (NC), a CL diet (CL), or a CL diet containing 0.003% β-cry...

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.

Barbara Renga
Andrea Mencarelli
Claudio D'Amore
Sabrina Cipriani
Maria Valeria D'Auria
Valentina Sepe
Maria Giovanna Chini
Maria Chiara Monti
Giuseppe Bifulco
Angela Zampella
Stefano Fiorucci

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastroin...

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Renga B.
Mencarelli A.
D'Amore C.
Cipriani S
D'AURIA, MARIA VALERIA
SEPE, VALENTINA
Chini M. G.
Monti M. C.
Bifulco G.
ZAMPELLA, ANGELA
Fiorucci S.

January 2012

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastroi...

Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.

Gillard, J.
Clerbaux, L.A.
Nachit, M.
Sempoux, C.
Staels, B.
Bindels, L.B.
Tailleux, A.
Leclercq, I.A.

January 2022

Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid and glucose metabolism, inflammation...

BDL causes liver cell injury and theonellasterol attenuates liver necrosis.

Barbara Renga (134135)
Andrea Mencarelli (134128)
Claudio D'Amore (134144)
Sabrina Cipriani (134132)
Maria Valeria D'Auria (186782)
Valentina Sepe (186788)
Maria Giovanna Chini (186796)
Maria Chiara Monti (186804)
Giuseppe Bifulco (186812)
Angela Zampella (186821)
Stefano Fiorucci (134151)

January 2012

(A and B) Liver necrosis was robustly attenuated by theonellasterol as confirmed by assess...

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

Renga Barbara
Mencarelli Andrea
D'Amore Claudio
Cipriani Sabrina
D'Auria Maria Valeria
Sepe Valentina
Chini Maria Giovanna
Monti Maria Chiara
Bifulco Giuseppe
Zampella Angela
Fiorucci Stefano

January 2012

. Here, we have characterized the activity of this theonellasterol on FXR-regulated genes and biolog...

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

Renga Barbara
Mencarelli Andrea
D'Amore Claudio
Cipriani Sabrina
D'Auria Maria Valeria
Sepe Valentina
Chini Maria Giovanna
Monti Maria Chiara
Bifulco Giuseppe
Zampella Angela
Fiorucci Stefano

January 2012

. Here, we have characterized the activity of this theonellasterol on FXR-regulated genes and biolog...

Bile acid genes expression differs between p53+/− and WT mice.

Francois Leblond (539482)
Steve Poirier (148055)
Carol Yu (539483)
Natacha Duquette (539484)
Gaetan Mayer (5658463)
Eric Thorin (539485)

March 2014

Hepatic mRNA expression of genes implicated in bile acid metabolism in WT and p53+/− 6...

Theonellasterol reverses the effect of CDCA on the expression of canonical FXR target genes.

Barbara Renga (134135)
Andrea Mencarelli (134128)
Claudio D'Amore (134144)
Sabrina Cipriani (134132)
Maria Valeria D'Auria (186782)
Valentina Sepe (186788)
Maria Giovanna Chini (186796)
Maria Chiara Monti (186804)
Giuseppe Bifulco (186812)
Angela Zampella (186821)
Stefano Fiorucci (134151)

January 2012

Relative mRNA expression of (A) OSTα, (B) BSEP, (C) SHP and (D) MRP4 in HepG2 cells treated with ...

Analysis of lipids and xenobiotics target genes expression in the liver.

Magali Foucaud-Vignault (343955)
Zeina Soayfane (343957)
Cécile Ménez (300702)
Justine Bertrand-Michel (76337)
Pascal Guy Pierre Martin (343960)
Hervé Guillou (343962)
Xavier Collet (76339)
Anne Lespine (300705)

February 2013

Relative gene expressions of scd-1, fasn, cd36, acox, cyp2B10 ...

Key mediators of bile acids (BA) synthesis in the liver of mice.

Francois Leblond (539482)
Steve Poirier (148055)
Carol Yu (539483)
Natacha Duquette (539484)
Gaetan Mayer (5658463)
Eric Thorin (539485)

March 2014

A) Transcription factors p53 and farnesoid X receptor (FXR) can activate the transcription of sma...

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

Barbara Renga (134135)
Andrea Mencarelli (134128)
Claudio D'Amore (134144)
Sabrina Cipriani (134132)
Maria Valeria D'Auria (186782)
Valentina Sepe (186788)
Maria Giovanna Chini (186796)
Maria Chiara Monti (186804)
Giuseppe Bifulco (186812)
Angela Zampella (186821)
Stefano Fiorucci (134151)

January 2012

<div><h3>Background</h3>The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liv...

Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet.

Kazuya Okushin
Takeya Tsutsumi
Kazuhiko Ikeuchi
Akira Kado
Kenichiro Enooku
Hidetaka Fujinaga
Naoko Yamauchi
Tetsuo Ushiku
Kyoji Moriya
Hiroshi Yotsuyanagi
Kazuhiko Koike

January 2020

The incidence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, including in Asian cou...

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Renga B.
Mencarelli A.
D'Amore C.
Cipriani S
D'AURIA, MARIA VALERIA
SEPE, VALENTINA
Chini M. G.
Monti M. C.
Bifulco G.
ZAMPELLA, ANGELA
Fiorucci S.

January 2012

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastroi...

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

Wang, Xiu Jun
Chamberlain, Mark
Vassieva, Olga
Henderson, Colin J.
Wolf, C. Roland

June 2005

Cytochrome P450 reductase is the unique electron donor for microsomal cytochrome P450s; these enzyme...

Hepatic gene expression levels significantly suppressed by β-cryptoxanthin in NASH.

Masuko Kobori (208009)
Yinhua Ni (307069)
Yumiko Takahashi (568105)
Natsumi Watanabe (568106)
Minoru Sugiura (292984)
Kazunori Ogawa (292986)
Mayumi Nagashimada (568107)
Shuichi Kaneko (156576)
Shigehiro Naito (53228)
Tsuguhito Ota (307055)

May 2014

C57BL/6J mice were fed a standard chow (NC), a CL diet (CL), or a CL diet containing 0.003% β-cry...

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.

Barbara Renga
Andrea Mencarelli
Claudio D'Amore
Sabrina Cipriani
Maria Valeria D'Auria
Valentina Sepe
Maria Giovanna Chini
Maria Chiara Monti
Giuseppe Bifulco
Angela Zampella
Stefano Fiorucci

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastroin...

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Renga B.
Mencarelli A.
D'Amore C.
Cipriani S
D'AURIA, MARIA VALERIA
SEPE, VALENTINA
Chini M. G.
Monti M. C.
Bifulco G.
ZAMPELLA, ANGELA
Fiorucci S.

January 2012

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastroi...

Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.

Gillard, J.
Clerbaux, L.A.
Nachit, M.
Sempoux, C.
Staels, B.
Bindels, L.B.
Tailleux, A.
Leclercq, I.A.

January 2022

Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid and glucose metabolism, inflammation...

<i>Theonellasterol</i> alters the liver expression of genes involved in bile acid metabolism in BDL mice.

Abstract

Extracted data

<i>Theonellasterol</i> alters the liver expression of genes involved in bile acid metabolism in BDL mice.

Abstract

Extracted data

Related items

Related items