Short-term plasticity at Cortico-LA synapses is perturbed in absence of αGDI.

<p>(<b>A</b>) Iterative stimulations (20 Hz/4 sec) were applied at Cortico-LA synapses in <i>Gdi1</i> WT and <i>Gdi1</i>-null mice. Scale bars: 50 (up) and 100 (bottom) pA and 250 msec. (<b>B</b>) The pronounced synaptic depression in <i>Gdi1</i>-null mice is well illustrated by the extraction of the last EPSCs of the train response. Scale bars: 50 (up) and 100 (bottom) pA and 10 msec. (<b>C</b>) Mean EPSC amplitude at a given stimulation for each genotype. (<b>D</b>) Cumulative plot based on the same data, allowing to visualize the deficit in refilling rate at <i>Gdi1</i>-null synapses (see material and methods section for further details). (<b>E₁</b>) Ready releasable pool size (RRP) and refilling rate (<b>E₂</b>) were calculated in <i>Gdi1</i>-null and <i>Gdi1</i> WT preparations and expressed as % of initial EPSC size. Number of recorded cells is indicated. **p<0,01.