The effects of delayed treatment in mice.

<p>Mice were infected with A/H5N1 and treated with (A) TCAD therapy or (B) OSL monotherapy. Treatments were given three times a day for 5 days starting at -4 (prophylaxis), 24, 48, or 72 hours after virus challenge, and survival and (C) maximum body weight loss were monitored over 21 days. Mice were treated with OSL (25 mg/kg/day) alone, or TCAD [AMT (46 mg/kg/day), OSL (25 mg/kg/day), and RBV (27 mg/kg/day)]. *P<0.05 versus placebo; *** P<0.05 versus OSL at the same treatment time point.