<i>Sox3</i> transgenic mice displayed CH.

<p><b>A,B:</b> H&E stained coronal section of adult <i>Sox3</i> transgenic mouse brain without (A) and with (B) overt hydrocephalus. Note the expanded lateral ventricles (LV), thinning of cerebral cortex (double-headed arrow) and hippocampal deformation (arrows) in the CH founder. <b>C,D: </b><i>Nr/+</i> adult mice showing dome-shaped cranium (arrow) due to overt CH (D) and normal cranial morphology (C). <b>E,F:</b> Nissl stained 18.5 dpc coronal brain sections of wild type (E) and <i>Sr/+;Nr/+</i> (F) 18.5 dpc embryonic brains. Note the expansion of the lateral ventricles (LV) in the transgenic embryo (F). Scale bar: 2 mm (A–B) and 1 mm (E–F).