The triple co-expression of Mieap, BNIP3, and NIX induces a remarkable reduction of MMP.

<p>HCT116 (A) and A549 (B) cells were infected with the indicated combinations of Ad-LacZ, Ad-NIX, Ad-BNIP3, Ad-Mieap α, and Ad-Mieap β, and 2 days after the infection, FACS analysis was performed to examine the MMP status. The experiment was repeated three times, and the representative result was shown. M1: rhodamine negative cells, M2: rhodamine positive cells. The experiment was independently carried out three times, and the representative result was shown.