Predicting behavior of <i>C. elegans</i> reproductive mutants.

<p>The reproductive dynamics of <i>tra-3</i> and <i>cdc-48.1</i> mutants at 20°C (dots; ±1 standard deviation) are well described by the model (solid lines are median predictions; dashed lines are ±1 standard deviation) (A). At 25°C, <i>tra-3</i> animals produce fewer progeny than predicted (B). Embryos are arranged in an orderly fashion in N2 animals at 20 (C) and 25°C (E) and in <i>tra-3</i> mutants at 20°C (D), but not at 25°C (F). Consequently, <i>tra-3</i> mutants retain more embryos in the uterus than N2 animals (G; average number per worm is shown; ±1 standard deviation). Bagging phenotype of <i>tra-3</i> mutants is rescued by an egg-laying constitutive mutation <i>egl-19</i>(ad695) (H).