Supplementary Material for: Interaction between <i>VEGF Receptor-2</i> Gene Polymorphisms and Dietary Patterns on Blood Glucose and Lipid Levels in Chinese Malaysian Adults

<i>Background/Aims:</i> The prevalence of lifestyle-related chronic diseases is increasing and gene-diet interaction studies are limited among the Malaysian population. This study was conducted to evaluate the association and interaction effects of <i>vascular endothelial growth factor receptor-2</i><i>(VEGFR2)</i> gene polymorphisms and dietary patterns on anthropometric and biochemical risk factors of chronic diseases in 179 Chinese Malaysian adults. <i>Methods:</i> Genotyping of rs1870377 and rs2071559 was performed by real-time PCR using TaqMan probes. Dietary patterns were constructed from the food frequency questionnaire using factor analysis. Anthropometric measurements: body mass index (BMI), systolic and diastolic blood pressure and biomarkers: blood glucose, glycated hemoglobin A1c (HbA1c) and lipids were obtained. <i>Results:</i> Two dietary patterns: ‘Balanced diet’ and ‘Meat, rice and noodles diet’ (MRND) were extracted. MRND was associated with higher BMI, blood pressure, blood glucose and lipids, while T alleles in both rs1870377 and rs2071559 were associated with higher blood lipids (p < 0.05). The interaction of MRND and rs1870377 had a borderline effect on blood HbA1c after adjusting for confounders (p = 0.057). <i>Conclusions:</i> A dietary pattern of MRND and <i>VEGFR2</i> gene polymorphisms were both associated with increased health risks of lifestyle-related chronic diseases particularly blood glucose and lipid levels in Chinese Malaysian adults